Pericardial metastases from BRCA1-associated peritoneal cancer. Case report
نویسندگان
چکیده
Women with BRCA1 gene mutations have about 30 to 40 times higher risk of ovarian cancer compared to the population risk (the lifetime risk of BRCA1-dependent ovarian cancer is about 40 percent). Because of the high risk BRCA1 mutations carriers at the age of about 40 are recommended prophylactic salpingo-oophorectomy (after completion of reproductive plans). After the surgery there is still a risk of peritoneal cancer which histologically resembles ovarian cancer, but it is much lower than the risk of ovarian cancer before salpingo-oophorectomy: the cumulative risk of developing cancer of the peritoneum is about 4 percent during 20 years from the removal of ovaries and fallopian tubes. We are going to present a case of long lasting diagnosis of pericardial metastases from BRCA1-associated peritoneal cancer.
منابع مشابه
Risk-reducing appendectomy and the elimination of BRCA1-associated intraperitoneal cancer.
Risk-reducing bilateral salpingo-oophorectomy (RRBSO) and risk-reducing mastectomy are widely used for BRCA1 and BRCA2 mutation carriers to reduce the risk of ovarian and breast cancer. To our knowledge, no risk-reduction therapy has addressed the BCRA1/2 carrier lifetime risk of intra-abdominal peritoneal carcinoma from an appendix source. We identified a BRCA1 carrier in a hereditary breast a...
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